Proteomic Analysis of Differentially Expressed Proteins in the Placenta of Anticardiolipin Antibody- (ACA-) Positive Pregnant Mice after Anzi Heji Treatment

Anzi Heji (AZHJ) has been used to deal with anticardiolipin antibody– (ACA-) optimistic pregnant ladies liable to spontaneous abortion for a few years. The intention of this research was to research the protecting mechanism of AZHJ in a mouse mannequin of ACA-positive being pregnant liable to spontaneous abortion utilizing label-free quantitative proteomics. Mice have been divided into three teams: regular pregnant mice (management group), ACA-positive pregnant mice administered regular saline (mannequin group), and ACA-positive pregnant mice administered AZHJ (AZHJ group).

The mannequin was established by injecting βproteomic and bioinformatic analyses. The degrees of IL-6, IL-10, ACA, and TNF-α within the serum and placentas of the mice have been measured by enzyme-linked immunosorbent assays (ELISAs). Proteomic information have been validated by western blot evaluation. The irregular serum and placental ranges of IL-6, ACA, and TNF-α within the mannequin group have been reversed by AZHJ. There have been 39 upregulated and 10 downregulated DEPs within the AZHJ group relative to the mannequin group.

Bioinformatic evaluation revealed that the DEPs have been primarily concerned in nucleic acid binding, sign conduction, and posttranslational modification. The placental ranges of T-cell immunoglobulin mucin 3 (Tim-3) and Toll-like receptor 4 (TLR4) expression and AKT phosphorylation within the three teams have been per the proteomic findings. Tim-3/AKT signaling is concerned in maternal-fetal immune tolerance, whereas TLR4 is related to inflammatory responses. Collectively, these outcomes point out that AZHJ might exert its protecting impact in ACA-positive pregnant mice by regulating the maternal-fetal immune tolerance and inflammatory response.

Merchandise have been subjected to liquid chromatography-tandem mass spectrometry (LC-MS/MS) evaluation and searched towards a UniProt Homo sapiens database. Relative protein abundance was decided for every pattern. Primarily based on proteomics outcomes, lumican was measured by enzyme-linked immunosorbent assay (ELISA) and Western blot evaluation was carried out for interleukin-1 receptor antagonist (IL-1Ra) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2). Cell viability was decided by calcein AM (stay) and ethidium homodimer (lifeless) staining and confocal microscopy.

Proteomic evaluation revealed 919 proteins within the 9 merchandise. Proteins have been primarily collagens, keratin, and albumin. Lumican, a small leucine-rich proteoglycan (SLRP) was present in all samples. Western blot evaluation for IL-1Ra and TIMP-2 indicated presence of each proteins, with nonspecific antibody binding additionally current in all samples. No stay cells have been recognized in any product.

Schwann Cell Stimulation of Pancreatic Most cancers Cells: A Proteomic Evaluation

Schwann cells (SCs), the glial element of peripheral nerves, have been recognized as promoters of pancreatic most cancers (PC) development, however the molecular mechanisms are unclear. Within the current research, we aimed to establish proteins launched by SCs that might stimulate PC progress and invasion. Proteomic evaluation of human major SC secretome was carried out utilizing liquid chromatography-tandem mass spectrometry, and a complete of 13,796 distinctive peptides comparable to 1,470 particular person proteins have been recognized.

Metabolic and cell-cell adhesion pathways confirmed the best ranges of enrichment, a discovering in step with the supportive function of SCs in peripheral nerves. We recognized seven SC-secreted proteins that have been validated by western blot. The involvement of those SC-secreted proteins was additional demonstrated by utilizing blocking antibodies. PC cell proliferation and invasion induced by SC-conditioned media have been decreased utilizing blocking antibodies towards the matrix metalloproteinase-2, cathepsin D, plasminogen activator inhibitor-1, and galectin-1.

Blocking antibodies towards the proteoglycan biglycan, galectin-Three binding protein, and tissue inhibitor of metalloproteinases-2 decreased solely the proliferation however not the invasion of PC cells. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment have been performed utilizing the Database for Annotation, Visualization, and Built-in Discovery. The elevated expression of phosphorylated ARPC2 discovered within the PBMCs of our sufferers, and its affiliation with derangement of F-actin filaments, would possibly recommend that proteins regulating actin dynamics in immune cells might be concerned within the mechanism of CAMR of kidney grafts.

Collectively, this research delineates the secretome of human SCs and identifies proteins that may stimulate PC cell progress and invasion and subsequently represent potential therapeutic targets. Altogether, 503 lysine succinylation websites in 303 proteins have been recognized. Lactate dehydrogenase A (LDHA), the important thing enzyme in Warburg impact, was discovered extremely succinylated at Ok222 in GC. Intriguingly, this modification didn’t have an effect on LDHA ubiquitination, however decreased the binding of ubiquitinated LDHA to SQSTM1, thereby lowering its lysosomal degradation.

Proteomic Analysis of Differentially Expressed Proteins in the Placenta of Anticardiolipin Antibody- (ACA-) Positive Pregnant Mice after Anzi Heji Treatment

Altered Phosphorylation of Cytoskeleton Proteins in Peripheral Blood Mononuclear Cells Characterizes Power Antibody-Mediated Rejection in Kidney Transplantation

Power antibody-mediated rejection (CAMR) is the key reason for kidney transplant failure. The molecular mechanisms underlying this occasion are nonetheless poorly outlined and this lack of understanding deeply influences the potential therapeutic methods. The intention of our research was to investigate the phosphoproteome of peripheral blood mononuclear cells (PBMCs), to establish mobile signaling networks differentially activated in CAMR. Phosphoproteins remoted from PBMCs of biopsy confirmed CAMR, kidney transplant recipients with regular graft operate and histology and wholesome immunocompetent people, have been investigated by proteomic evaluation.

QuECHERS GC/NPD and LC/MS

QUECR-NPD-MS-IS EACH
EUR 197.22

QuECHERS GC/MS Int Std

QUECR-MS-IS EACH
EUR 90.06

QuECHERS GC/MS QCSTD2

QUECR-MS-QC-2 EACH
EUR 189.24

Naled (Dibrom) Standard in LC/MS Acetonitrile

LCS-2650 1ML
EUR 52.44

QuECHERS GC/MS QCSTD1 04

QUECR-MS-QC-1 EACH
EUR 182.4

Triclosan 1000 ug/mL in LC/MS Methanol

LCS-4382 1ML
EUR 281.58

Acequinocyl in LC/MS Acetonitrile 1000 ug/mL 1mL

LCS-6394 1ML
EUR 71.82

AlbuVoid™ Kit

AVK-05 5 preps
EUR 486
Description: Albumin Removal Kit

AlbuVoid™ Kit

AVK-10 10 preps
EUR 662.4
Description: Albumin Removal Kit

AlbuVoid™ Kit

AVK-50 50 preps
EUR 1856.4
Description: Albumin Removal Kit

MagSi-proteomics C18

MD01009 2 mL
EUR 391.2

MagSi-proteomics C4

MD01014 2 mL
EUR 391.2

MagSi-proteomics C8

MD01015 2 mL
EUR 391.2

MagSi-proteomics C4

MD02014 10 mL
EUR 1332

MagSi-proteomics C8

MD02015 10 mL
EUR 1332

MagSi-proteomics C18

MD03009 10 mL
EUR 1332

MagSi-proteomics C4

MD03014 100 mL
EUR 7260

MagSi-proteomics C8

MD03015 100 mL
EUR 7260

MagSi-proteomics C18

MD04009 100 mL
EUR 7260

Human Osteonectin (ON) ELISA Kit

DLR-ON-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Osteonectin (ON) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Osteonectin (ON) ELISA Kit

DLR-ON-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Osteonectin (ON) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Osteonectin (ON) ELISA Kit

DLR-ON-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Osteonectin (ON) ELISA Kit

DLR-ON-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Osteonectin (ON) ELISA Kit

DLR-ON-Ra-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Osteonectin (ON) ELISA Kit

DLR-ON-Ra-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Osteonectin (ON) ELISA Kit

RD-ON-Hu-48Tests 48 Tests
EUR 573.6

Human Osteonectin (ON) ELISA Kit

RD-ON-Hu-96Tests 96 Tests
EUR 794.4

Mouse Osteonectin (ON) ELISA Kit

RD-ON-Mu-48Tests 48 Tests
EUR 586.8

Mouse Osteonectin (ON) ELISA Kit

RD-ON-Mu-96Tests 96 Tests
EUR 812.4

Rat Osteonectin (ON) ELISA Kit

RD-ON-Ra-48Tests 48 Tests
EUR 613.2

Rat Osteonectin (ON) ELISA Kit

RD-ON-Ra-96Tests 96 Tests
EUR 850.8

Human Osteonectin (ON) ELISA Kit

RDR-ON-Hu-48Tests 48 Tests
EUR 600

Human Osteonectin (ON) ELISA Kit

RDR-ON-Hu-96Tests 96 Tests
EUR 830.4

Mouse Osteonectin (ON) ELISA Kit

RDR-ON-Mu-48Tests 48 Tests
EUR 613.2

Mouse Osteonectin (ON) ELISA Kit

RDR-ON-Mu-96Tests 96 Tests
EUR 850.8

Rat Osteonectin (ON) ELISA Kit

RDR-ON-Ra-48Tests 48 Tests
EUR 640.8

Rat Osteonectin (ON) ELISA Kit

RDR-ON-Ra-96Tests 96 Tests
EUR 890.4

LC-LC(+)-Biotin

abx184150-5g 5 g
EUR 1195.2

AGAROSE MS, PCR SCREENING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE

AGR-MS-1001 1/pk
EUR 2445.6
Description: Bioscience Mol Bio; Agarose

Biotin-LC-LC-NHS

2346-1000
EUR 2010

Biotin-LC-LC-NHS

2346-250
EUR 705.6

Biotin-LC-LC-NHS

2346-50
EUR 235.2

Biotin-LC-LC-NHS

2346-5000 Ask for price

AlbuVoid Binding Buffer AVBB

AVBB-1000 1000 mL
EUR 547.2
Description: Albuvoid™ Buffer

AlbuVoid Binding Buffer AVBB

AVBB-500 500 mL
EUR 294
Description: Albuvoid™ Buffer

AlbuVoid Buffer Kit - 1000

AVBK-1000 1000 mL
EUR 1399.2
Description: Albuvoid™ Buffer

AlbuVoid Buffer Kit - 500

AVBK-500 500 mL
EUR 738
Description: Albuvoid™ Buffer

AlbuVoid Elution Buffer AVEB

AVEB-1000 1000 mL
EUR 547.2
Description: Albuvoid™ Buffer

AlbuVoid Elution Buffer AVEB

AVEB-500 500 mL
EUR 294
Description: Albuvoid™ Buffer

AlbuVoid Wash Buffer AVWB

AVWB-1000 1000 mL
EUR 547.2
Description: Albuvoid™ Buffer

AlbuVoid Wash Buffer AVWB

AVWB-500 500 mL
EUR 294
Description: Albuvoid™ Buffer

AlbuVoid™ PLUS Kit

NP-AVK-05 5 preps
EUR 486
Description: Albumin Removal Kit

AlbuVoid™ PLUS Kit

NP-AVK10 10 preps
EUR 704.4
Description: Albumin Removal Kit

Trypsin, Recombinant, Proteomics grade

P1228-1000
EUR 235.2

Trypsin, Recombinant, Proteomics grade

P1228-10000
EUR 1468.8

Trypsin, Recombinant, Proteomics grade

P1228-5000
EUR 738

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (3 biotin/BSA)

7097-25
EUR 266.4

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (3 biotin/BSA)

7097-5
EUR 138

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)

7098-25
EUR 279.6

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)

7098-5
EUR 144

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (12 biotin/BSA)

7099-25
EUR 292.8

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (12 biotin/BSA)

7099-5
EUR 157.2

Micro Bead Sterlizer

B1201-E 1 PC
EUR 651.24

Micro Bead Sterlizer

B1202-E 1 PC
EUR 100.97

Refill Glass Beads

B1201-BEAD 1 PC
EUR 141.34

101Bio Protein Solubilization Reagent for MS

P5W11 - Ask for price

MS-1020

1911-1
EUR 196.8

MS 275

abx076834-1mg 1 mg
EUR 376.8

Ms-275

20-abx182582
  • EUR 610.80
  • EUR 360.00
  • 100 mg
  • 10 mg

MS-1020

GL5031-1MG 1 mg
EUR 192

LC-Protein Kinase G Substrate; LC-Gsubtide (Biotin)

20-abx265657
  • EUR 560.40
  • EUR 927.60
  • EUR 427.20
  • 10 mg
  • 25 mg
  • 5 mg

Kinesis Bearing Assembly Shimadzu LC-6; LC-6A

CHR6124 EACH
EUR 149.34

Bangs Lab Bead Solution

SOLN1-1000 1000 ML
EUR 186.07
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres

Bangs Lab Bead Solution

SOLN1-2000 2000 ML
EUR 255.24
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres

Bangs Lab Bead Solution

SOLN1-500 500 ML
EUR 118.21
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres

NHS-LC-Biotin

A8004-100 100 mg
EUR 142.8
Description: NHS-LC-biotin (succinimidyl-6-(biotinamindo)hexanoate), also known as NHS-X-biotin is a derivative of D-biotin, a amine-reactive biotinylation agent, that contains a spacer arm off the valeric acid side chain of D-biotin with an NHS ester group at its end.

NHS-LC-Biotin

A8004-1000 1 g
EUR 657.6
Description: NHS-LC-biotin (succinimidyl-6-(biotinamindo)hexanoate), also known as NHS-X-biotin is a derivative of D-biotin, a amine-reactive biotinylation agent, that contains a spacer arm off the valeric acid side chain of D-biotin with an NHS ester group at its end.

Iodoacetyl-LC-Biotin

A8009-100 100 mg
EUR 316.8
Description: Iodoacetyl-LC-Biotin (N-iodoacetyl-N-biotinylhexylenediamine), a sulfhydryl-reactive biotinylation agent, is a water-insoluble reagent that requires the dissolution of suitable solvents, including dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).

sulfo-LC-SPDP

ADC-L-133 unit Ask for price

CD49f LC antibody

70R-49925 100 ul
EUR 292.8
Description: Purified Polyclonal CD49f LC antibody

CD49e LC antibody

70R-49932 100 ul
EUR 292.8
Description: Purified Polyclonal CD49e LC antibody

Biotin-LC-Kemptide

5-00800 4 x 1mg Ask for price

Kininogen LC antibody

23031-100ul 100ul
EUR 468

Sulfo-LC-SPDP

2325-250
EUR 1880.4

Sulfo-LC-SPDP

2325-50
EUR 523.2

Biotin-LC-NHS

2345-1000
EUR 1201.2

Biotin-LC-NHS

2345-250
EUR 502.8

Biotin-LC-NHS

2345-50
EUR 170.4

CD224 LC Antibody

20-abx121054
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Enteropeptidase LC Antibody

20-abx121089
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

MASP1 LC Antibody

20-abx121154
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Myeloperoxidase LC Antibody

20-abx121172
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

CD49e LC Antibody

20-abx009097
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

CD49f LC Antibody

20-abx009102
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

sulfo-LC-(+)-Biotin

20-abx185570
  • EUR 444.00
  • EUR 1513.20
  • EUR 693.60
  • 100 mg
  • 1 g
  • 250 mg

LC-(+)-Biotin hydrazide

abx185659-1g 1 g
EUR 777.6

LC-NHS-(+)-Biotin

20-abx185861
  • EUR 760.80
  • EUR 477.60
  • 1 g
  • 250 mg

Biotin LC hydrazide

HY-101885 5mg
EUR 142.8

pPINK- LC Plasmid

PVT4035 2 ug
EUR 390

LC-Pak polisher

LCPAK00A1 EACH
EUR 802.56

ELISA kit for Human MS (Melatonin Sulfate)

E-EL-H1726 1 plate of 96 wells
EUR 640.8
Description: A competitive ELISA kit for quantitative measurement of Human MS (Melatonin Sulfate) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Melatonin sulfate (MS)

KTE61523-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Melatonin sulfate (MS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Melatonin sulfate (MS)

KTE61523-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Melatonin sulfate (MS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Melatonin sulfate (MS)

KTE61523-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Melatonin sulfate (MS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Marking labels for microplates (on sheets for printing)

DD53080 PK3120
EUR 131.1

ELISA kit for Human ON (Osteonectin)

E-EL-H1351 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse ON (Osteonectin)

E-EL-M0867 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat ON (Osteonectin)

E-EL-R0701 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human ON (Osteonectin)

E-CL-H0889 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse ON (Osteonectin)

E-CL-M0530 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat ON (Osteonectin)

E-CL-R0498 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Rat ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ON (Osteonectin)

ELK1682 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Osteonectin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Rat ON (Osteonectin)

ELK1683 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Osteonectin from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Mouse ON (Osteonectin)

ELK1684 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Osteonectin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human Osteonectin (ON)

KTE60336-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Osteonectin (ON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Osteonectin (ON)

KTE60336-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Osteonectin (ON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Osteonectin (ON)

KTE60336-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Osteonectin (ON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

AffiPure Ni-NTA Agarose Bead,For His-Tagged Protein Purification

N3505-010 10ml
EUR 380.4

AffiPure Ni-NTA Agarose Bead,For His-Tagged Protein Purification

N3505-050 50ml
EUR 999.6

Biotin-LC-Protein Kinase G Substrate; Biotin-LC-G-Subtide

5-00802 4 x 5mg Ask for price

CM Rapid Run Agarose Bead

CMRR-25 25 ml
EUR 122.4

CM Rapid Run Agarose Bead

CMRR-300 300 ml
EUR 590.4

DEAE Rapid Run Agarose Bead

DEAERR-25 25 ml
EUR 122.4

DEAE Rapid Run Agarose Bead

DEAERR-300 300 ml
EUR 590.4

Bead Sample Pack - 50mL Set

BSP-50B2 1pack
EUR 484.8
Description: Bead sample pack for Bullet Blender 50mL tube models. Includes 20mL of: ZROB05, ZROB20, SSB02, SSB14B, SSB48, SSB60, SSUFO35 and SSUFO56.

Bead Sample Pack - 5E Set

BSP-5E 1pack
EUR 302.4
Description: Bead sample pack for Bullet Blender 5E models. Includes 10mL of: ZROB015, ZROB05, ZROB20, SSB02, SSB14B, SSB32, SSB48, SSUFO35 and SSUFO56.

Bead Sample Pack - 5M Set

BSP-5Y 1pack
EUR 289.2
Description: Bead sample pack for Bullet Blender 5mL Storm models. Includes 10mL of: ZROB015, ZROB05, ZROB20, SSB02, SSB14B, SSB32, SSB60, SSB110 and SSUFO35.

Bead Sample Pack - Full Set

BSP-ALL2 1pack
EUR 460.8
Description: Bead sample pack inlcudes sampling of all 20 bead types in 10mL tubes.

Bead Sample Pack - Cell Cultures

BSP-CC2 1pack
EUR 234
Description: Bead sample pack for homogenization of cell cultures. Includes 10mL of: GB01, GB05, ZROB015, ZROB05 and SSB02.

Bead Sample Pack - Microcentrifuge Set

BSP-MC2 1pack
EUR 278.4
Description: Bead sample pack for Bullet Blender 1.5mL tube models. Includes 10mL of: ZROB015, ZROB05, ZROB10, ZROB20, SSB02, SSB14B, SSB32 and SSUFO35.

Bead Sample Pack - Organ Tissues

BSP-OT3 1pack
EUR 282
Description: Bead sample pack for homogenization of organ tissues. Includes 10mL of: ZROB05, ZROB10, ZROB20, SSB14B, SSB32 and SSUFO35.

SP Rapid Run Agarose Bead

SPRR-25 25 ml
EUR 122.4

SP Rapid Run Agarose Bead

SPRR-300 300 ml
EUR 590.4

Glass bead diameter 1 mm

DD68499 EACH
EUR 26.68

Glass bead diameter 2 mm

DD68500 EACH
EUR 37.62

Glass bead diameter 3mm 500g

DD68501 EACH
EUR 39.9

Glass bead diameter 4 mm

DD68502 EACH
EUR 35.34

Glass bead diameter 5 mm

DD68503 EACH
EUR 37.62

Glass bead diameter 6 mm

DD68504 EACH
EUR 36.48

Glass bead diameter 8 mm

DD68505 BAG
EUR 42.64

Glass bead diameter 10 mm

DD68555 EACH
EUR 42.52

ExoFACS? Kit for Serum Exosomes

K1233-20
EUR 952.8

MS-275 (Entinostat)

E1KS1053 25 mg
EUR 296.4

Methyl-PEG3-MS

abx186609-250mg 250 mg
EUR 526.8

MS 245 oxalate

B5540-10 10 mg
EUR 350.4

MS 245 oxalate

B5540-5 5 mg
EUR 252

Ab MS GluR1*

P80000-100uL 100uL Ask for price

uv lamp 2x15w, 254/365nm

VL215-LC ea
EUR 980.4

uv lamp 2x6w, 254/365nm

VL6-LC ea
EUR 645.6

darkroom 254/365nm

VLCN15-LC ea
EUR 1842

Sulfo-NHS-LC-Biotin

A8003-100 100 mg
EUR 170.4
Description: Sulfo-NHS-LC-biotin (Sulfosuccinimidyl 6-(biotinamido) Hexanoate) is an amine-reactive biotinylation agent.

Sulfo-NHS-LC-Biotin

A8003-1000 1 g
EUR 686.4
Description: Sulfo-NHS-LC-biotin (Sulfosuccinimidyl 6-(biotinamido) Hexanoate) is an amine-reactive biotinylation agent.

Complement C1R LC antibody

70R-49435 100 ul
EUR 292.8
Description: Purified Polyclonal Complement C1R LC antibody

Cathepsin D LC antibody

70R-49618 100 ul
EUR 292.8
Description: Purified Polyclonal Cathepsin D LC antibody

Sulfo-NHS-LC-Biotin

2326-100
EUR 373.2

Sulfo-NHS-LC-Biotin

2326-50
EUR 242.4

Sulfo-NHS-LC-Biotin

2326-set
EUR 255.6

CD224 LC Blocking Peptide

20-abx161054
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Enteropeptidase LC Blocking Peptide

20-abx161089
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

MASP1 LC Blocking Peptide

20-abx161154
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Myeloperoxidase LC Blocking Peptide

20-abx161172
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Cathepsin C LC Antibody

20-abx121043
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Phosphoproteomic outcomes have been confirmed by Western blot and PBMCs’ confocal microscopy analyses. General, 38 PBMCs samples have been analyzed. A differential evaluation of PBMCs’ phosphoproteomes revealed a rise of lactotransferrin, actin-related protein 2 (ARPC2) and calgranulin-B in antibody-mediated rejection sufferers, in comparison with controls. Elevated expression of phosphorylated ARPC2 and its correlation to F-actin filaments have been confirmed in CAMR sufferers. Our outcomes are the primary proof of altered cytoskeleton group in circulating immune cells of CAMR sufferers.

 

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